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Table 5 Functional annotation of the top ten superfamilies that have either the largest number of HMM representations or CCs.

From: A Network of SCOP Hidden Markov Models and Its Analysis

Superfamily ID

# of HMMs

# of CCs

Functional annotation

c.37.1

358

3

P-loop containing nucleoside triphosphate hydrolases

b.1.1

286

6

Immunoglobulin

c.2.1

267

2

NAD(P)-binding Rossmann-fold domains

a.4.5

150

20

Winged helix DNA-binding domain

c.47.1

147

4

Thioredoxin-like

c.1.8

141

7

(Trans)glycosidases

c.66.1

119

2

S-adenosyl-L-methionine-dependent methyltransferases

a.4.1

110

8

Homeodomain-like

c.69.1

106

1

alpha/beta-Hydrolases

b.1.2

98

2

Fibronectin type III

Superfamily ID

# of CCs

# of HMMs

Functional annotation

a.4.5

20

150

Winged helix DNA-binding domain

b.1.18

17

76

E set domains

b.40.4

16

95

Nucleic acid-binding proteins

b.29.1

14

97

Concanavalin A-like lectins/glucanases

d.14.1

11

52

Ribosomal protein S5 domain 2-like

g.39.1

10

83

Glucocorticoid receptor-like (DNA-binding domain)

b.18.1

10

54

Galactose-binding domain-like

d.3.1

10

54

Cysteine proteinases

a.4.1

8

110

Homeodomain-like

b.121.4

8

58

Positive stranded ssRNA viruses