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Table 5 Functional annotation of the top ten superfamilies that have either the largest number of HMM representations or CCs.

From: A Network of SCOP Hidden Markov Models and Its Analysis

Superfamily ID # of HMMs # of CCs Functional annotation
c.37.1 358 3 P-loop containing nucleoside triphosphate hydrolases
b.1.1 286 6 Immunoglobulin
c.2.1 267 2 NAD(P)-binding Rossmann-fold domains
a.4.5 150 20 Winged helix DNA-binding domain
c.47.1 147 4 Thioredoxin-like
c.1.8 141 7 (Trans)glycosidases
c.66.1 119 2 S-adenosyl-L-methionine-dependent methyltransferases
a.4.1 110 8 Homeodomain-like
c.69.1 106 1 alpha/beta-Hydrolases
b.1.2 98 2 Fibronectin type III
Superfamily ID # of CCs # of HMMs Functional annotation
a.4.5 20 150 Winged helix DNA-binding domain
b.1.18 17 76 E set domains
b.40.4 16 95 Nucleic acid-binding proteins
b.29.1 14 97 Concanavalin A-like lectins/glucanases
d.14.1 11 52 Ribosomal protein S5 domain 2-like
g.39.1 10 83 Glucocorticoid receptor-like (DNA-binding domain)
b.18.1 10 54 Galactose-binding domain-like
d.3.1 10 54 Cysteine proteinases
a.4.1 8 110 Homeodomain-like
b.121.4 8 58 Positive stranded ssRNA viruses