Table 1 Summary for pathway analyses
models | Top Canonical Pathways | -log(B_H p-value) | Ratio |
|---|---|---|---|
Linear Amp | Estrogen receptor signaling | 6.95e-01 | 15/135 (0.111) |
Pyrimidine Metabolism | 3.31e-01 | 15/151 (0.099) | |
Mitochondrial Dysfunction | 3.31e-01 | 13/127 (0.102) | |
Molecular Mechanisms of Cancer | 1.77e-01 | 25/359 (0.07) | |
Oxidative Phosphorylation | 1.77-01 | 13/140 (0.093) | |
Linear Del | Purine metabolism | 1.1e00 | 23/303 (0.076) |
DNA Methylation and Transcriptional Repression Signaling | 5.24e-01 | 4/23 (0.174) | |
Reelin Signaling in Neurons | 5.24e-01 | 8/82 (0.098) | |
Pyrimidine Metabolism | 5.24e-01 | 12/151 (0.079) | |
Toll-like Receptor Signaling | 5.24e-01 | 6/51 (0.118) | |
Quad Amp | P13K/AKT signaling | 1.93e00 | 9/132 (0.068) |
Neuregulin signaling | 1.49e00 | 7/98 (0.071) | |
PTEN signaling | 4.97e-01 | 6/120 (0.05) | |
TR/RXR activation | 2.95e-01 | 5/93 (0.054) | |
ERK5 Signaling | 2.74e-01 | 4/67 (0.06) | |
Quad Del | Cell cycle regulation by BTG family proteins | 1.88e00 | 5/36 (0.139) |
CTLA4 signaling in cytotoxic T lymphocytes | 1.83e00 | 7/98 (0.071) | |
Ceramide signaling | 1.48e00 | 6/85 (0.071) | |
Wnt/ß-catenin signaling | 6.97e-01 | 7/173 (0.04) | |
IL-2 signaling | 6.97e-01 | 4/59 (0.068) | |
models | Top Associated Network Functions | Score | |
Linear Amp | Embryonic Development, Tissue Development, DNA Replication, Recombination, and Repair | 41 | |
Dermatological Diseases and Conditions, Genetic Disorder, Metabolic Disease | 35 | ||
Cell Signaling, RNA Post-Transcriptional Modification, Gene Expression | 35 | ||
Gene Expression, Cellular Compromise, Cardiovascular System Development and Function | 35 | ||
Cellular Development, Carbohydrate Metabolism, Lipid Metabolism | 33 | ||
Linear Del | Cellular assembly and organization, Cellular function and maintenance, DNA replication, Recombination, and Repair | 37 | |
RNA Post-Transcriptional Modification, Gene Expression, Immunological Disease | 37 | ||
Embryonic Development, Cell Morphology, Cellular Development | 37 | ||
Gene Expression, Cell Cycle, Cellular Development | 33 | ||
Cellular Movement, Nervous System Development and Function, Cellular Assembly and Organization | 27 | ||
Quad Amp | Molecular Transport, Small Molecule Biochemistry, Cell Cycle | 44 | |
Gene Expression, Cancer, Gastrointestinal Disease | 41 | ||
Cell Morphology, Cell-To-Cell Signaling and Interaction, Cellular Assembly and Organization | 26 | ||
Gene Expression, Endocrine System Disorders, Genetic Disorder | 21 | ||
Gene Expression, Connective Tissue Disorders, Immunological Disease | 19 | ||
Quad Del | Cell Cycle, Carbohydrate Metabolism, Lipid Metabolism | 45 | |
Organismal Injury and Abnormalities, Cellular Development, Cell Death | 23 | ||
Post-Translational Modification, Protein Degradation, Protein Synthesis | 21 | ||
Cellular Assembly and Organization, Nervous System Development and Function, Cell-To-Cell Signaling and Interact | 21 | ||
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking | 19 | ||
models | Diseases and disorders | B-H p-value | # Molecules |
Linear Amp | Cancer | 2.24e-05 - 4.45e-01 | 120 |
Reproductive system disease | 2.24e-05 - 4.39e-01 | 86 | |
Development disorder | 6.55 e -02 - 4.39e-01 | 19 | |
Inflammatory response | 3.77e-01 - 4.39e-01 | 5 | |
Genetic disorder | 4.39e-01 - 4.39e-01 | 38 | |
Linear Del | Cancer | 4,27e-06 - 2.4e-01 | 102 |
Reproductive system disease | 4.27e-06 - 2.4e-01 | 75 | |
Infectious disease | 6.9e-03 - 2.4e-01 | 58 | |
Infection mechanism | 7.62e-03 - 2.4e-01 | 60 | |
Dermatological Diseases and Conditions | 9.78e-02 - 2.4e-01 | 28 | |
Quad Amp | Cancer | 6.54e-03 - 1.68e-01 | 73 |
Reproductive system disease | 6.54e-03 - 1.68e-01 | 34 | |
Gastrointestinal disease | 1.57e-01 - 1.68e-01 | 9 | |
Hepatic system disease | 1.57e-01 - 1.68e-01 | 8 | |
Inflammatory disease | 1.57e-01 - 1.68e-01 | 12 | |
Quad Del | Genetic disorder | 1.54e-01 - 2.11e-01 | 33 |
Neurological disease | 1.54e-01 - 2.11e-01 | 24 | |
Psychological disorders | 1.54e-01 - 2.11e-01 | 18 | |
Cancer | 1.54e-01 - 2.11e-01 | 15 | |
Metabolic Disease | 1.54e-01 - 2.11e-01 | 7 | |
models | Molecular and Cellular Functions | B-H p-value | # Molecules |
Linear Amp | Gene expression | 5.23e-03 - 4.45e-01 | 133 |
Cell death | 1.21e-01 - 4.45e-01 | 50 | |
Cellular growth and proliferation | 1.21e-01 - 4.39e-01 | 33 | |
Molecular transport | 3.77e-01 - 4.39e-01 | 52 | |
Protein trafficking | 3.77e-01 - 4.39e-01 | 24 | |
Linear Del | Cellular assembly and organization | 1.47e-05 - 2.4e-01 | 75 |
Cellular function and maintenance | 1.47e-05 - 2.4e-01 | 44 | |
Cellular development | 2.56e-02 - 2.4e-01 | 39 | |
Cellular growth and proliferation | 2.56e-02 - 2.4e-01 | 15 | |
DNA replication, recombination, and repair | 4.28e-02 - 2.4e-01 | 41 | |
Quad Amp | Cellular development | 1.57e-01 - 1.68e-01 | 20 |
Cell death | 1.57e-01 - 1.68e-01 | 25 | |
Cell cycle | 1.57e-01 - 1.68e-01 | 16 | |
Cell morphology | 1.57e-01 - 1.68e-01 | 24 | |
Gene expression | 1.57e-01 - 1.68e-01 | 23 | |
Quad Del | Post-translation modification | 1.54e-01 - 2.11e-01 | 19 |
Cell morphology | 1.54e-01 - 2.11e-01 | 13 | |
Cellular development | 1.54e-01 - 2.11e-01 | 14 | |
Carbohydrate metabolism | 1.54e-01 - 2.11e-01 | 9 | |
Lipid metabolism | 1.54e-01 - 2.11e-01 | 16 | |