Table 2 The 20 Most Significant Gene Sets from the ASD Dataset for Deletions
From: A scan statistic to extract causal gene clusters from case-control genome-wide rare CNV data
Gene Set Name | nominal p-value | FDR q-value | Holm's p-value | Overlap proportion |
|---|---|---|---|---|
NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON | 1.876E-05 | 0.061 | 0.061 | 0.051 |
PEREZ_TP53_TARGETS | 9.768E-05 | 0.078 | 0.319 | 0.019 |
REACTOME_RNA_POLYMERASE_I_III_AND_MITOCHONDRIAL_TRANSCRIPTION | 1.026E-04 | 0.078 | 0.336 | 0.092 |
ONKEN_UVEAL_MELANOMA_UP | 1.065E-04 | 0.078 | 0.348 | 0.098 |
BROWNE_HCMV_INFECTION_24HR_DN | 1.187E-04 | 0.078 | 0.388 | 0.065 |
REACTOME_RNA_POLYMERASE_I_PROMOTER_CLEARANCE | 1.490E-04 | 0.081 | 0.487 | 0.098 |
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP | 1.937E-04 | 0.091 | 0.633 | 0.052 |
STARK_HYPPOCAMPUS_22Q11_DELETION_DN | 0.001 | 0.218 | 1.000 | 0.115 |
KEGG_GAP_JUNCTION | 0.001 | 0.218 | 1.000 | 0.133 |
DAIRKEE_TERT_TARGETS_UP | 0.001 | 0.218 | 1.000 | 0.111 |
BLALOCK_ALZHEIMERS_DISEASE_UP | 0.001 | 0.229 | 1.000 | 0.062 |
RODWELL_AGING_KIDNEY_UP | 0.001 | 0.229 | 1.000 | 0.067 |
WALLACE_PROSTATE_CANCER_RACE_UP | 0.001 | 0.268 | 1.000 | 0.035 |
AMUNDSON_RESPONSE_TO_ARSENITE | 0.001 | 0.284 | 1.000 | 0.105 |
NIKOLSKY_BREAST_CANCER_16P13_AMPLICON | 0.001 | 0.284 | 1.000 | 0.050 |
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP | 0.001 | 0.284 | 1.000 | 0.039 |
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN | 0.001 | 0.284 | 1.000 | 0.123 |
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP | 0.002 | 0.327 | 1.000 | 0.045 |
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP | 0.002 | 0.341 | 1.000 | 0.057 |
HSIAO_HOUSEKEEPING_GENES | 0.002 | 0.360 | 1.000 | 0.260 |