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Table 5 Top ranking co-occurring domains in high confidence binding sites from human

From: Binding Site Prediction for Protein-Protein Interactions and Novel Motif Discovery using Re-occurring Polypeptide Sequences

Domain Name A

Domain Name B

DOMINE

SH2 motif

Serine-threonine/tyrosine-protein kinase

Known

Serine-threonine/tyrosine-protein kinase

Insulin receptor substrate-1, PTB

Known

PDZ/DHR/GLGF

Cyclic AMP-dependent chloride channel

Novel

Serine-threonine/tyrosine-protein kinase

Phosphotyrosine interaction domain

Known

Serine-threonine/tyrosine-protein kinase

Serine-threonine/tyrosine-protein kinase

Known

PDZ/DHR/GLGF

Tyrosine-protein kinase, CSF-1/PDGF receptor

Novel

Src homology-3 domain

Serine/threonine-protein kinase-like domain

Known

SH2 motif

SH2 motif

Known

Src homology-3 domain

T-cell adhesion molecule CD2

Novel

7TM GPCR, rhodopsin-like

PDZ/DHR/GLGF

Known

  1. Binding sites included in this analysis had DM ≤ 0.20. Among interacting domain pairs in all sites, 22 out of 47 (46.8%) pairs are reported in the DOMINE database.