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Table 1 Boundaries of Safe, Twilight and Dark Zones used by NPS-HomPPIa.

From: HomPPI: a class of sequence homology based protein-protein interface prediction methods

  log(EVal) ≤ -100
Safe Zone Positive Score ≥80%
  log(LAL) ≥5.2
  log(EVal) ≤ -50
Twilight Zone 1 b Positive Score ≥65%
  log(LAL) ≥4
  log(EVal) ≤ 1
Twilight Zone 2 b Positive Score ≥60%
  log(LAL) ≥4
  log(EVal) ≤ 1
Dark Zone Positive Score ≥0
  log(LAL) ≥0
  1. a Thresholds were chosen based on interface conservation analysis of proteins in Trans135.
  2. b Twilight Zone is divided into two sub-zones: Twilight Zone 1 with stricter thresholds, and Twilight Zone 2 with looser thresholds.