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Table 1 Boundaries of Safe, Twilight and Dark Zones used by NPS-HomPPIa.

From: HomPPI: a class of sequence homology based protein-protein interface prediction methods

 

log(EVal)

≤ -100

Safe Zone

Positive Score

≥80%

 

log(LAL)

≥5.2

 

log(EVal)

≤ -50

Twilight Zone 1 b

Positive Score

≥65%

 

log(LAL)

≥4

 

log(EVal)

≤ 1

Twilight Zone 2 b

Positive Score

≥60%

 

log(LAL)

≥4

 

log(EVal)

≤ 1

Dark Zone

Positive Score

≥0

 

log(LAL)

≥0

  1. a Thresholds were chosen based on interface conservation analysis of proteins in Trans135.
  2. b Twilight Zone is divided into two sub-zones: Twilight Zone 1 with stricter thresholds, and Twilight Zone 2 with looser thresholds.