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Table 3 Prediction Performance of NPS-HomPPI using Homologs from the Safe, Twilight, Dark Zones.

From: HomPPI: a class of sequence homology based protein-protein interface prediction methods

Binding Type Homology Zone Prediction Coverage CCP SensitivityP SpecificityP AccuracyP
  Safe 14% (5/36) 0.55 0.62 0.57 0.94
Enzyme-inhibitor, - Transient Twilight 50% (18/36) 0.52 0.69 0.58 0.83
  Dark 19% (7/36) 0.12 0.23 0.20 0.83
  Total 83% (30/36) 0.44 0.58 0.50 0.85
  Safe 23% (7/30) 0.56 0.64 0.60 0.91
Non-enzyme-inhibitor, - Transient (NEIT) Twilight 37% (11/30) 0.37 0.48 0.57 0.78
  Dark 33% (10/30) 0.36 0.37 0.50 0.86
  Total 93% (28/30) 0.42 0.48 0.55 0.84
  Safe 52% (14/27) 0.70 0.81 0.72 0.91
Hetero-dimer, - Obligate Twilight 33% (9/27) 0.52 0.58 0.64 0.82
  Dark 15% (4/27) 0.44 0.66 0.47 0.80
  Total 96% (26/27) 0.60 0.71 0.66 0.86
  Safe 38% (33/87) 0.84 0.90 0.84 0.96
Homo-dimer, - Obligate Twilight 31% (27/87) 0.67 0.74 0.71 0.91
  Dark 28% (24/87) 0.36 0.47 0.44 0.84
  Total 97% (84/87) 0.65 0.73 0.68 0.91