Table 1 Gene modules of the obesity related genes
From: DOSim: An R package for similarity between diseases based on Disease Ontology
Cluster | Size | Average similarity | p-value# | FDR* | Representative GO annotation§ | Representative KEGG annotation§ |
|---|---|---|---|---|---|---|
M1 | 92 | 0.43 | <1.0E-05 | <1.0E-04 | cholesterol homeostasis; high-density lipoprotein particle remodelling; triglyceride catabolic process | Insulin signaling pathway; Type II diabetes mellitus |
M2 | 60 | 0.30 | 0.25 | 0.28 | N/A$ | Pyruvate metabolism; Galactose metabolism; |
M3 | 55 | 0.30 | 0.29 | 0.29 | feeding behavior; photoreceptor cell maintenance | Neuroactive ligand-receptor interaction; Circadian rhythm - mammal; |
M4 | 31 | 0.50 | <1.0E-05 | <1.0E-04 | response to estrogen stimulus; response to cytokine stimulus; cell aging | Pathways in cancer; Colorectal cancer; Endometrial cancer; |
M5 | 30 | 0.62 | <1.0E-05 | <1.0E-04 | response to lipopolysaccharide; response to glucocorticoid stimulus | Cytokine-cytokine receptor interaction; Toll-like receptor signaling pathway; |
M6 | 23 | 0.55 | <1.0E-05 | <1.0E-04 | positive regulation of phosphoinositide 3-kinase cascade; positive regulation of cholesterol esterification | Renin-angiotensin system; Prostate cancer |
M7 | 15 | 0.34 | 0.12 | 0.16 | N/A | Insulin signaling pathway |
M8 | 15 | 0.43 | 6.0E-04 | 6.0E-03 | blood coagulation; STAT protein nuclear translocation | Complement and coagulation cascades; Regulation of actin cytoskeleton |
M9 | 15 | 0.53 | <1.0E-05 | <1.0E-04 | response to interleukin-1; response to glucocorticoid stimulus | Hematopoietic cell lineage; Cytokine-cytokine receptor interaction |
M10 | 12 | 0.40 | 1.5E-02 | 2.2E-02 | N/A | N/A |