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Table 1 Gene modules of the obesity related genes

From: DOSim: An R package for similarity between diseases based on Disease Ontology

Cluster Size Average similarity p-value# FDR* Representative GO annotation§ Representative KEGG annotation§
M1 92 0.43 <1.0E-05 <1.0E-04 cholesterol homeostasis; high-density lipoprotein particle remodelling; triglyceride catabolic process Insulin signaling pathway; Type II diabetes mellitus
M2 60 0.30 0.25 0.28 N/A$ Pyruvate metabolism; Galactose metabolism;
M3 55 0.30 0.29 0.29 feeding behavior; photoreceptor cell maintenance Neuroactive ligand-receptor interaction; Circadian rhythm - mammal;
M4 31 0.50 <1.0E-05 <1.0E-04 response to estrogen stimulus; response to cytokine stimulus; cell aging Pathways in cancer; Colorectal cancer; Endometrial cancer;
M5 30 0.62 <1.0E-05 <1.0E-04 response to lipopolysaccharide; response to glucocorticoid stimulus Cytokine-cytokine receptor interaction; Toll-like receptor signaling pathway;
M6 23 0.55 <1.0E-05 <1.0E-04 positive regulation of phosphoinositide 3-kinase cascade; positive regulation of cholesterol esterification Renin-angiotensin system; Prostate cancer
M7 15 0.34 0.12 0.16 N/A Insulin signaling pathway
M8 15 0.43 6.0E-04 6.0E-03 blood coagulation; STAT protein nuclear translocation Complement and coagulation cascades; Regulation of actin cytoskeleton
M9 15 0.53 <1.0E-05 <1.0E-04 response to interleukin-1; response to glucocorticoid stimulus Hematopoietic cell lineage; Cytokine-cytokine receptor interaction
M10 12 0.40 1.5E-02 2.2E-02 N/A N/A
  1. # the original p-value calculated by permutation
  2. * FDR using Benjamini and Hochberg multiple testing correlations
  3. § Refer to Additional file 3 for complete GO and KEGG annotations.
  4. $ N/A indicates that there are no enriched GO or KEGG annotation for this module.