Figure 10

Summary of crosstalk relationship graphs for the yeast cell cycle. Crosstalk relationship graphs (Figure 6, 7, 8 and 9) belonging to the same phase were combined to form one graph. The associations mediated by Cdc28, cyclins, and CDC genes during G2 and M phase were merged into the graph of G2 phase. Only the most essential and specific associations of each crosstalk relationship graph that were demonstrated are shown. The references for these crosstalk associations are listed in Additional file 1 Table A2. The center of the summary graph shows each phase of the cell cycle. Each graph is placed according to the related stage of the cell cycle. In the graph, yellow boxes labeled "module ID" indicate modules, and green circles indicate regulators not contained in any modules. Phase-related regulators contained in a module are listed under the circle presenting the module. Links indicate either relationships dependent on protein-protein interactions (blue links) or relationships dependent on transcriptional regulation (red or purple links). Only relationships among correlated genes and their correlated module pairs were used to construct the relationship graphs (see the Methods section for details).