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Table 4 More # of 2-degree cyclic atoms, degree of cyclization and # of non-H polar bonds could increase the potency of HIV Reverse Transcriptase Inhibitors.

From: Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study

Precursor Structure pKi
#5
log(1/EC50): 8.3
+ 3.88% (× 27.2)
#5
log(1/EC50): 8.3
+ 3.77% (× 26.8)
#5
log(1/EC50): 8.3
+ 3.39% (× 26.4)
#5
log(1/EC50): 8.3
+ 3.39% (× 26.3)
#5
log(1/EC50): 8.3
+ 3.36% (× 26.3)
#5
log(1/EC50): 8.3
+ 3.31% (× 26.6)
#5
log(1/EC50): 8.3
+ 3.32% (× 26.3)