Table 4 More # of 2-degree cyclic atoms, degree of cyclization and # of non-H polar bonds could increase the potency of HIV Reverse Transcriptase Inhibitors.
From: Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study
Precursor | Structure | pKi | |
|---|---|---|---|
#5 log(1/EC50): 8.3 |
|
| + 3.88% (× 27.2) |
#5 log(1/EC50): 8.3 |
|
| + 3.77% (× 26.8) |
#5 log(1/EC50): 8.3 |
|
| + 3.39% (× 26.4) |
#5 log(1/EC50): 8.3 |
|
| + 3.39% (× 26.3) |
#5 log(1/EC50): 8.3 |
|
| + 3.36% (× 26.3) |
#5 log(1/EC50): 8.3 |
|
| + 3.31% (× 26.6) |
#5 log(1/EC50): 8.3 |
|
| + 3.32% (× 26.3) |
