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Table 6 5 More # of non-H, # of non-H polar bonds and # of rotatable bonds could increase the potency of HCV NS5B Inhibitors.

From: Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study

Precursor

Structure

IC50(uM)NS5B

#15

IC50(uM)NS5B: 1.64

+ 2.51%

(× 25.2)

#15

IC50(uM)NS5B: 1.64

+ 2.18%

(× 24.5)

#15

IC50(uM)NS5B: 1.64

+ 1.63%

(× 27.5)

#15

IC50(uM)NS5B: 1.64

+ 1.19%

(× 24.1)

#15

IC50(uM)NS5B: 1.64

+ 0.98%

(× 24.1)

#15

IC50(uM)NS5B: 1.64

+ 0.91%

(× 24.3)

#15

IC50(uM)NS5B: 1.64

+ 0.79%

(× 24.2)

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BMC Bioinformatics

ISSN: 1471-2105

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