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Table 6 5 More # of non-H, # of non-H polar bonds and # of rotatable bonds could increase the potency of HCV NS5B Inhibitors.

From: Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study

Precursor Structure IC50(uM)NS5B
#15
IC50(uM)NS5B: 1.64
+ 2.51%
(× 25.2)
#15
IC50(uM)NS5B: 1.64
+ 2.18%
(× 24.5)
#15
IC50(uM)NS5B: 1.64
+ 1.63%
(× 27.5)
#15
IC50(uM)NS5B: 1.64
+ 1.19%
(× 24.1)
#15
IC50(uM)NS5B: 1.64
+ 0.98%
(× 24.1)
#15
IC50(uM)NS5B: 1.64
+ 0.91%
(× 24.3)
#15
IC50(uM)NS5B: 1.64
+ 0.79%
(× 24.2)
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