Table 6 5 More # of non-H, # of non-H polar bonds and # of rotatable bonds could increase the potency of HCV NS5B Inhibitors.
From: Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study
| Precursor | Structure | IC50(uM)NS5B | |
|---|---|---|---|
|
#15 IC50(uM)NS5B: 1.64 |
|
|
+ 2.51% (× 25.2) |
|
#15 IC50(uM)NS5B: 1.64 |
|
|
+ 2.18% (× 24.5) |
|
#15 IC50(uM)NS5B: 1.64 |
|
|
+ 1.63% (× 27.5) |
|
#15 IC50(uM)NS5B: 1.64 |
|
|
+ 1.19% (× 24.1) |
|
#15 IC50(uM)NS5B: 1.64 |
|
|
+ 0.98% (× 24.1) |
|
#15 IC50(uM)NS5B: 1.64 |
|
|
+ 0.91% (× 24.3) |
|
#15 IC50(uM)NS5B: 1.64 |
|
|
+ 0.79% (× 24.2) |