Figure 1
From: Differential C3NET reveals disease networks of direct physical interactions
Examples of direct physical gene interactions. Examples of direct (A, C, E) and non-direct (B, D) physical gene interactions. G, P are for gene and protein (or transcription factor), respectively. Direct: Fig 1A. G1 encodes P1 that directly regulates G2, Fig 1C. G1 encodes a kinase protein that phosphorylates P2 that regulates G2, Fig 1E. G1 encodes P1 that makes protein complex with P2 that is also encoded by G2. Non-direct: Fig 1B. G3 encodes P3 that regulates both G1 and G2, Fig 1D. G1 encodes P1 that regulates G3 that encodes P3 that regulates G2.