Screenshot of the VisToolBox. This tool provides several methods to explore and analyze the signal domain of multivariate images (MVI). It consists of an image viewer (a) and a panel (b) including methods from the fields of visualization, e.g. creating pseudo color fusion images from selected images (c), co-location analysis and exploratory data analysis (EDA). The small figures below exemplary show further exploration displays: (d) Histogram. (e) Scatter plot. The parallel coordinates plot in (f) depicts the multivariate pixel information of all nine images of the MVI in a compact display. Each vertical compound line represents an unique location within a user-defined image region and shows the corresponding signals of all images at that location. In (g) a co-location study of two images with statistical measurements (Manders' score and Pearson correlation coefficient) is displayed.