Figure 2

Simulation results from the CPME model with deterministic reaction dynamics. The simulations for panels (a) and (b) start with a single cell close to the off-state, while the simulations for panels (c) and (d) start with a single cell close to the on-state. [I _ex ] = 24 μM for all simulations and all other parameters as in Table 3. Panels (a) and (c): Transients for all the cells in the corresponding populations. Panels (b) and (d): The solid lines show the dynamics of the population mean for the total LacY concentration for the simulations of panel (a) and (c) respectively. The dashed lines indicate the total number of cells for the corresponding simulations. The constant number technique is used for times greater than 415 min (when N _cellsmax = 10⁴).