Rigorous assessment and integration of the sequence and structure based features to predict hot spots

BMC Bioinformatics

Table 1 Statistical analysis on evolutionary conservation score and sequence entropy between hot spots and non-hot spots

	Evolutionary conservation score		Sequence entropy
	Ab+	Ab-	Ab+	Ab-
Hot spots^a	4.46	5.63	45.84	35.14
Non-hot spots^b	4.08	4.28	47.87	44.59
P-value	0.14	10^-4	0.36	1.1 × 10^-3

Ab+ represents the database contains all complexes. Ab- represents the database excludes antigen-antibody complexes.
^a Mean value of hot spots.
^b Mean value of non-hot spots

ISSN: 1471-2105