Figure 4

A. Absolute domain architecture conservation of duplicated orthologs and 1-1 orthologs. The average DA-score for each protein pair type is shown for comparisons between human and other species, sorted by their distance to human. Domain architecture is clearly more conserved in clusters where no gene duplication has taken place. The scores for each pair type are first averaged within each cluster so that each cluster contributes equally to the average scores regardless of size. B. Sequence divergence of duplicated orthologs and 1-1 orthologs. The average number of substitutions per position for each protein pair type is shown for comparisons between human and other species, sorted by their distance to human. The greatest divergence between the pair types is seen for comparisons of human vs non-primate vertebrates.