A schematic illustration of the DRENDA work flow. The BRENDA enzyme names and synonyms and the MeSH disease terms are used as dictionaries. The PubMed abstracts and titles are searched for co-occurring disease and enzyme entities. A test/train corpus was created for training an SVM and classifying the co-occurrence results according to the categories causal interaction, therapeutic application, diagnostic usage and ongoing research. The resulting entries are stored in the DRENDA database.