Figure 3

The pedigree structure of the simulated example. Squares (males) and circles (females) filled with black indicate affected members. Individual 2 is the disease founder. The disease is assumed to fit an autosomal dominant model with complete penetrance. Bars denote chromosome groups of each member; red bars are groups that were simulated to take the disease-causal mutations (black regions); other colored bars, including green and light brown, are the unaffected chromosome groups.