An integrative approach to ortholog prediction for disease-focused and other functional studies

BMC Bioinformatics

Table 4 Comparison of Drosophila disease genes identified from OMIM/GWAS and fly disease genes identified by literature mining

Disease Category	Fly disease genes mapped from OMIM/GWAS	Fly disease genes from OMIM/GWAS that are studied in disease in literature	Fly disease genes from OMIM/GWAS with disease categories confirmed by literature	% of fly disease genes with disease categories confirmed by literature
Congenital, Hereditary, and Neonatal Diseases and Abnormalities	2614	707	539	76%
Otorhinolaryngologic Diseases	996	12	8	67%
Nervous System Diseases	1901	669	431	64%
Musculoskeletal Diseases	1433	88	56	64%
Cardiovascular Diseases	1140	95	58	61%
Stomatognathic Diseases	761	14	8	57%
Skin and Connective Tissue Diseases	1349	72	36	50%
Digestive System Diseases	1397	66	31	47%
Hemic and Lymphatic Diseases	775	64	27	42%
Neoplasms	673	382	145	38%
Male Urogenital Diseases	1069	202	75	37%
Eye Diseases	1356	334	120	36%
Respiratory Tract Diseases	639	6	2	33%
Immune System Diseases	523	56	18	32%
Female Urogenital Diseases and Pregnancy Complications	1041	236	72	31%
Mental Disorders	906	345	105	30%
Endocrine System Diseases	627	94	27	29%
Nutritional and Metabolic Diseases	896	255	71	28%
Parasitic Diseases	28	122	2	2%
Pathological Conditions, Signs and Symptoms	489	1074	143	13%
Bacterial Infections and Mycoses	36	133	14	11%
Disorders of Environmental Origin	1768	358		0%
Virus Diseases	48	24	0	0%
Substance-Related Disorders	17		0	0%
All Categories	4282	1534	888	58%

ISSN: 1471-2105