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Table 4 Comparison of Drosophila disease genes identified from OMIM/GWAS and fly disease genes identified by literature mining

From: An integrative approach to ortholog prediction for disease-focused and other functional studies

Disease Category Fly disease genes mapped from OMIM/GWAS Fly disease genes from OMIM/GWAS that are studied in disease in literature Fly disease genes from OMIM/GWAS with disease categories confirmed by literature % of fly disease genes with disease categories confirmed by literature
Congenital, Hereditary, and Neonatal Diseases and Abnormalities 2614 707 539 76%
Otorhinolaryngologic Diseases 996 12 8 67%
Nervous System Diseases 1901 669 431 64%
Musculoskeletal Diseases 1433 88 56 64%
Cardiovascular Diseases 1140 95 58 61%
Stomatognathic Diseases 761 14 8 57%
Skin and Connective Tissue Diseases 1349 72 36 50%
Digestive System Diseases 1397 66 31 47%
Hemic and Lymphatic Diseases 775 64 27 42%
Neoplasms 673 382 145 38%
Male Urogenital Diseases 1069 202 75 37%
Eye Diseases 1356 334 120 36%
Respiratory Tract Diseases 639 6 2 33%
Immune System Diseases 523 56 18 32%
Female Urogenital Diseases and Pregnancy Complications 1041 236 72 31%
Mental Disorders 906 345 105 30%
Endocrine System Diseases 627 94 27 29%
Nutritional and Metabolic Diseases 896 255 71 28%
Parasitic Diseases 28 122 2 2%
Pathological Conditions, Signs and Symptoms 489 1074 143 13%
Bacterial Infections and Mycoses 36 133 14 11%
Disorders of Environmental Origin 1768 358   0%
Virus Diseases 48 24 0 0%
Substance-Related Disorders 17   0 0%
All Categories 4282 1534 888 58%