Figure 1
From: Methodology and software to detect viral integration site hot-spots
![Figure 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1471-2105-12-367/MediaObjects/12859_2011_Article_4830_Fig1_HTML.jpg)
Definition of CIS, BCP and z-threshold hot-spot methods. (A) The CIS hot-spot definition implemented here is based on a commonly used density metric [19, 21]. (B) Our 'z-threshold' and 'BCP' hot-spot definitions operate on a partition of the genome into 1 Mb bins. The number of VIS per megabase bin is tallied and then converted to a z-score by subtracting the mean and dividing by the standard error, calculated across all bins. Bins with high z-scores are called 'hot-bins'. Hot-spots are defined by grouping consecutive hot-bins and setting each external boundary to the closest VIS.