|  | # Hot-Spots | % VIS in HS | % Coverage | Size (Mb) | % Density* |
---|
Data Set
|
Total VIS
|
BCP
|
CIS
|
BCP
|
CIS
|
BCP
|
CIS
|
BCP
|
CIS
|
BCP
|
CIS
|
H-LV-acute | 922 | 3 | 11 | 2.93 | 5.1 | 0.101 | 0.02 | 1.045 | 0.055 | 0.93 | 8.98 |
H-LV-XALD | 2401 | 5 | 110 | 6.21 | 22.7 | 0.213 | 0.246 | 1.316 | 0.069 | 0.86 | 2.95 |
H-LV-Patient1 | 1627 | 6 | 56 | 7.74 | 15.86 | 0.251 | 0.119 | 1.291 | 0.066 | 0.96 | 4.69 |
H-LV-Patient2 | 774 | 6 | 12 | 5.56 | 5.81 | 0.17 | 0.018 | 0.874 | 0.047 | 1.04 | 10.07 |
H-MLV-acute | 1398 | 0 | 15 | 0 | 3.93 | 0 | 0.017 | 0 | 0.035 | 0 | 7.29 |
H-MLV-XCGD | 384 | 2 | 3 | 16.93 | 16.67 | 0.037 | 0.009 | 0.564 | 0.09 | 165.32 | 228.5 |
H-MLV-SCIDX1 | 864 | 7 | 22 | 5.9 | 11 | 0.045 | 0.029 | 0.197 | 0.041 | 4.02 | 13.82 |
- Relative to the CIS method, the BCP hot-spot definition identified fewer hot-spots containing a smaller percentage of VIS for all data sets. It also gave the most consistent results across the full X-linked ALD data set, and patients 1 and 2. The % VIS in hot-spots (HS) ranged from 5.56% to 7.74% for the BCP method and 5.81% to 22.7% using the CIS hot-spot definition. The CIS definition found similar hot-spot numbers and % VIS in hot-spots for the acute infection data set and post-transplant data for patient 2. Both the BCP and CIS methods indicate differences in hot-spot patterns between the LV and MLV data sets. In particular, the CGD study data had very few hot-spots with high VIS densities. % Density was calculated as (Median # VIS per HS/# Total VIS)*100/Mb. Data set names are as in Table 1.