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Table 3 BCP hot-spots for the LV acute infection, full X-linked ALD, and patient 1 and 2 data sets.

From: Methodology and software to detect viral integration site hot-spots

Data set # VIS Chr Location (Mb) # VIS (%) Size (Mb) % Density
H-LV-acute 922 Chr 11 65.020-65.721 12 (1.30%) 0.7 1.86
H-LV-acute 922 Chr 16 0.425-1.929 7 (0.76%) 1.5 0.51
H-LV-acute 922 Chr 17 77.185-78.117 8 (0.87%) 0.93 0.93
Median - - - 8 (0.87%) 0.93 0.93
H-LV-XALD 2401 Chr 6 31.967-33.000 35 (1.46%) 1.03 1.41
H-LV-XALD 2401 Chr 11 64.005-66.969 61 (2.54%) 2.96 0.86
H-LV-XALD 2401 Chr 12 6.085-6.993 16 (0.67%) 0.91 0.73
H-LV-XALD 2401 Chr 17 2.000-2.522 17 (0.71%) 0.52 1.36
H-LV-XALD 2401 Chr 17 73.098-74.252 20 (0.83%) 1.15 0.72
Median - - - 20 (0.83%) 1.03 0.86
H-Patient1 1627 Chr 6 31.967-33.000 25 (1.54%) 1.03 1.49
H-Patient1 1627 Chr 11 64.019-66.969 47 (2.89%) 2.95 0.98
H-Patient1 1627 Chr 12 6.085-6.993 14 (0.86%) 0.91 0.95
H-Patient1 1627 Chr 17 73.098-74.252 15 (0.92%) 1.15 0.8
H-Patient1 1627 Chr 17 77.093-77.863 13 (0.8%) 0.77 1.04
H-Patient1 1627 Chr 19 53.882-54.813 12 (0.74%) 0.93 0.79
Median - - - 14.5 (0.89%) 0.98 0.965
H-Patient2 774 Chr 1 2.038-2.954 6 (0.78%) 0.92 0.85
H-Patient2 774 Chr 3 47.057-47.926 6 (0.78%) 0.87 0.89
H-Patient2 774 Chr 6 31.867-32.976 11 (1.42%) 1.11 1.28
H-Patient2 774 Chr 16 0.592-1.838 7 (0.9%) 1.25 0.73
H-Patient2 774 Chr 17 2.000-2.452 7 (0.9%) 0.45 2
H-Patient2 774 Chr 17 76.215-76.864 6 (0.78%) 0.65 1.19
Median - - - 6.5 (0.84%) 0.89 1.04
  1. Five hot-spots were identified by the BCP method for the post infection X-linked ALD data set, ranging in size from 0.52-2.96 Mb with a median density of 0.86% total VIS/Mb. When the ALD study patients were analyzed separately, six hot-spots were observed for each patient with similar sizes and densities. Patient 1 had four hot-spots that overlapped with the full X-linked ALD data set on chromosomes (Chr) 6, 11, 12 and 17; as well as two additional hot-spots on Chr 17 and 19. Patient 2 had two hot-spots that overlapped with the full data set on Chr 6 and 17, as well as four additional hot-spots on Chr 1, 3, 16 and 17. In comparison, the acute infection data with three hot-spots had one overlap with the full ALD data set on Chr 11, a unique hot-spot on Chr 16, and a hot-spot on Chr 17 that overlapped with Patient 1's Chr 17 hot-spot. % Density was calculated as (# VIS per HS/# Total VIS)*100/Mb. Data set names are as in Table 1.