Significance testing in ridge regression for genetic data

BMC Bioinformatics

Table 3 Multiple causal phenotypes

Performance comparison between a permutation test and the approximate test in simulated genotype data with continuous phenotypes and multiple causal SNPs. Reported are proportion of true positive and false positive results at significance threshold α = 0.05. n = 500 and in each scenario ten SNPs are with MAF 0.10 - 0.15 are designated causal with effect size 1; the rest of the SNPs have 0 effect size. TPR = True Positive Rate, FPR = False positive rate. Results for each simulation scenario are averaged over ten replicates.

ISSN: 1471-2105