Significance testing in ridge regression for genetic data

BMC Bioinformatics

Table 6 Lung cancer data

SNP (chromosome)	Univariate p-value	Multivariate p-value unpenalised	Approximate p-value λ= 150	Permutation p-value λ= 150
rs8034191 (15q25)	0.009	0.603	0.007	0.006
rs16969968 (15q25)	0.001	0.183	0.001	0.000
rs402710 (5p15)	0.213	0.012	0.011	0.004
rs4324798 (6p21)	0.513	0.231	0.248	0.251

Of the 35 SNPs in the lung cancer data set, four have been previously reported to be associated with lung cancer disease status. For these four SNPs, this table reports univariate, multivariate, approximate and permutation test p-values.

ISSN: 1471-2105