Figure 2
From: iCTNet: A Cytoscape plugin to produce and analyze integrative complex traits networks
A network of five common autoimmune diseases. A. Disease-gene interaction network (ds = 0) for five common autoimmune diseases. Each disease has unique and shared associations. RA, T1D, and MS are closely related both through HLA and non-HLA associated genes. B. A simplified version of the network shown in A, using the "create similarity net" feature of iCTNet. In this representation, diseases are connected by edges of a color proportional to the number of shared genes. C. Same network as in A with drug-target interactions. Colored circles represent diseases (MS = yellow, T1D = red, RA = green, Ps = magenta, CD = teal), white triangles represent genes, and cyan round squares represent drugs. Disease-gene interactions are colored according to the disease. Protein-protein and DNA-protein interactions are shown as white edges. Drug-gene interactions are represented as cyan dashed edges.