Figure 6

Disease group browsing. This example shows how iRefScape can be used to locate all the proteins connected with a certain disease and group them according to a selected property. The figure is not meant to show node or edge details, rather to demonstrate the search and the subsequent filtering. In this figure the results of the search type = digid for query "197" (breast cancer) with iteration set to 0 are shown. All the oval shaped nodes represent proteins from the genes in this group. The hexagons represent membership in the same n-ary interaction record. Subsequent to the search, a filter was applied to select all nodes which have the gene ontology function annotation "DNA binding". During the filtering, grouping was requested (by setting the "group mode on" under filters). This has resulted in three groups (1, 2 and 3 in the figure). Group 1 contains nodes with the annotation "DNA binding". Group 2 contains nodes which do not have the annotation "DNA binding" but have a direct interaction or a complex membership with nodes in Group 1. Group 3 contains the remaining nodes that do not belong to Groups 1 and 2. The set of nodes marked with number 4 shows the n-ary interaction records where at least one node with the annotation and one without the annotation were involved.