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Figure 2 | BMC Bioinformatics

Figure 2

From: SCOWLP update: 3D classification of protein-protein, -peptide, -saccharide and -nucleic acid interactions, and structure-based binding inferences across folds

Figure 2

SCOWLP applications: a) The same binding region of the protein family "heat-shock transcription factor" (blue ribbon) presents interfaces for DNA (left, pdb:3hts) and protein (right, pdb:1fbq); b) Schematic representation of the method used to infer binding regions and interfaces. Two proteins from different SCOP families (violet and red) present structural resemblances. Since violet protein interacts with its green ligand through a region that is conserved in the violet-red structural alignment, violet's binding region is inferred to the red protein, suggesting that it could also recognize other proteins through this inferred region in a similar binding mode to violet-green interface.

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BMC Bioinformatics

ISSN: 1471-2105

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