Figure 2
From: Predicting protein ligand binding motions with the conformation explorer
Applying Euler rotations to M domain. Rotations are applied about the z-axis, Rz(θz), about the x-axis, Rx(θx), and about the y-axis, Ry(θy), in that order. The explored space of rotational orientations of the M domain spans ± 80° in the y and z directions and -20° to 80° in the x-direction. Rotations about x, y, and z axes (Ry(θy), Rx(θx), and Rz(θz)) result in putative alternate conformations. The standard orientation described in the text is such that the center of mass (COM) of L is at the origin, COM of M domain is along the z-axis, and COM of S is in the negative-y part of yz plane.