DoBo: Protein domain boundary prediction by integrating evolutionary signals and machine learning

BMC Bioinformatics

Table 4 Precision and recall of domain boundary predictions on CASP9 continuous, multi-domain targets

Predictor	Precision of Domain Boundary Prediction	Recall of Domain Boundaries
DOMPro	0.50	0.14
PPRODO	0.50	0.52
DoBo	0.49	0.70

For the 14 continuous, multi-domain targets from CASP9, we used DOMPro, PPRODO and our method DoBo to predicted domain boundaries. Only domain boundary predictions which were more than 40 residues from the N or C terminal end of a sequence were considered. A domain boundary prediction is considered correct if it occurs within 20 residues of a true domain boundary. The recall value is calculated for domain boundaries which occur at least 40 residues from the N or C terminal end of a sequence.

ISSN: 1471-2105