Figure 4

The pattern of model simulation compare with experimental data. Simulations profile of our model (Upper boxes) and coresponding original data [2, 17, 18]. Blue bars represent on and white space means off, respectively. X-axis is the time course (minutes) and y-axis means the activities of target in our model in distinct conditions: (A) IKK (left) and NFkB’s (right) activities induced by TNF 45 minutes treatment with wild type and A20 mutant. (B) IKK (left) and NFkB’s (right) activities with wild type and A20 knockout condition of LPS 45 minutes treatment. (C) NFkB’s activities induced by transient 15 minutes IL-1 in wild type and IκBα mutant. (D) IkBa’s activities with TNF (left) and LPS (right) 45 minutes stimuli.