Table 1 The model obtained by our approach
From: A genetic algorithm-based boolean delay model of intracellular signal transduction in inflammation
Component | Boolean transfer function |
|---|---|
IRAK1(t) | = 5*IL1(t-1) OR 3*LPS(t-87) |
TAB1/TAB2/TAK1(t) | = IRAK1(t-13) OR LPS(t-125) |
NIK(t) | = TAB1/TAB2/TAK1(t-25) OR TNFR1(t-1) |
IKK(t) | = TAB1/TAB2/TAK1(t-100) OR NIK(t-1) |
IkBa(t) | = NOT 2* IKK(t-3) OR -62* NFkB(t-96) |
NFkB(t) | = NOT IkBa(t-1) |
A20(t) | = 7*NFkB(t-107) |
IL1(t) | = -62*NFkB(t-373) |
TNF(t) | = -62*NFkB(t-69) |
TNFR1(t) | = 4*TNF(t-1) AND NOT A20(t-10) |