Increase in the number of useful edges with increasing A. (a) A schematic illustration of the impact of designs on the number of useful edges. As there is a larger number of SNP pairs with small distances, designs that favor short edges tend to connect already connected components, and have less useful edges. (b) The fraction of useful edges for two designs, and for a range of values for A. Note that a large fraction of edges (reads) is wasted either because the edges do not connect two variants, or because the they connect already connected components. The design with longer advance lengths always has a larger fraction of useful edges resulting in better AN50. Simulations used L = 900bp, c = 20×, A = 9kbp.