Figure 3
From: Integrated metabolome and transcriptome analysis of the NCI60 dataset
Outlier analysis. Outlier analysis shows extreme gene-metabolite pairs could be resulted from cell specific mutations. Top scatter plots: NOTCH1 ~ X-2005, with outlier in cell line MOLT_4 and KRAS ~ X-2690, with outlier in OVCAR5. It can be seen that the high PCC were both artefacts of extreme outliers. Middle table: PCC and PQC of the corresponding pairs, before and after outlier removal. R_QC: PQC. R_QC_RM: PQC after outlier removal. P_Pearson: PCC. R_P_RM: PCC after outlier removal. Bottom table: annotated mutation records from Sanger Cosmic database, directly matched to these two outlier pairs.