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Figure 1 | BMC Bioinformatics

Figure 1

From: Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway

Figure 1

Two proposed initiation models of canonical Wnt/β-catenin signalling pathways. In the sequential recruitment/amplification model (left), Wnt-induced FZD-LRP6 complex formation promotes initial LRP6 phosphorylation via DVL recruitment of the AXIN-GSK3 complex. Initial LRP6 phosphorylation provides docking sites and thereby recruits additional AXIN-GSK3 complex to promote further LRP6 phosphorylation if LRP6 multimerizes. In the signalosome/aggregation model (right), Wnt induces clustering of LRP6, leading to its phosphorylation by CK1 and subsequently by GSK3 and recruitment of AXIN.

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BMC Bioinformatics

ISSN: 1471-2105

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