In silico modification of suberoylanilide hydroxamic acid (SAHA) as potential inhibitor for class II histone deacetylase (HDAC)

Table 9 Toxicity of SAHA standard and modified ligand based on Toxtree v2.1.0.

Ligand	*Negatif for genotoxic carcinogenity*	*Negatif for nongenotoxic carcinogenity*	*Potential S.Typhiurium TA 100 mutagen based on QSAR*	*Potential carcinogen based on QSAR*
SAHA	yes	yes	no	no
1a	yes	yes	no	no
1b	no	yes	no	no
1c	yes	yes	no	no
1d	yes	no	no	no
1e	yes	yes	no	no
1f	yes	no	no	no
2a	yes	yes	no	no
2b	no	yes	yes	no
2c	yes	yes	no	no
2d	yes	no	no	yes
2e	yes	yes	no	no
2f	yes	no	no	no

ISSN: 1471-2105