Characterization of pathogenic germline mutations in human Protein Kinases

BMC Bioinformatics

Table 1 Results of the Xd analysis comparing PD_PKs and SNP_PKs

Feature	PD (Å)	SNP (Å)	∆Xd
Conservation - Shannon	7.17	6.71	-0.13
Conservation - AL2CO	8.49	10.49	-0.52
Structural Conservation	7.56	7.00	2.10
Accessibility - Buried	2.94	3.63	-0.83
Catalytic - FireDB	8.69	12.66	-4.74
Catalytic - Knight	11.89	16.26	-2.33
TreeDeterminants	6.00	7.94	-1.98

Where PD (Å) and SNP (Å) stand for the average closest distances in Angstroms from the feature residue and the PDs and SNPs respectively, and ∆Xd for the difference in Xd values. Negative values indicate that the PDs are closer to the feature residues whereas positive values indicate that SNPs are in the surroundings of feature residues.

ISSN: 1471-2105