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Table 1 Results of the Xd analysis comparing PD PK s and SNP PK s

From: Characterization of pathogenic germline mutations in human Protein Kinases

Feature PD (Å) SNP (Å) ∆Xd
Conservation - Shannon 7.17 6.71 -0.13
Conservation - AL2CO 8.49 10.49 -0.52
Structural Conservation 7.56 7.00 2.10
Accessibility - Buried 2.94 3.63 -0.83
Catalytic - FireDB 8.69 12.66 -4.74
Catalytic - Knight 11.89 16.26 -2.33
TreeDeterminants 6.00 7.94 -1.98
  1. Where PD (Å) and SNP (Å) stand for the average closest distances in Angstroms from the feature residue and the PDs and SNPs respectively, and ∆Xd for the difference in Xd values. Negative values indicate that the PDs are closer to the feature residues whereas positive values indicate that SNPs are in the surroundings of feature residues.