Relationship between Delta and accuracy in chromosome 21 of Hirschsprung study. Illustration of the accuracy obtained in chromosome 21 of Hirschsprung data set when change Δ value from 0 to 10. For chromosome 21, in each trial, all the 451 samples of both control and case were randomly divided into 10 equal partitions. For each of the 10 partition groups, we selected one of them as testing set and the remaining nine of them were considered as training sets. 10 trials were considered and the results were collected based on this 10-fold cross validation procedure. This figure was drawn based on one of these ten trails when the highest accuracy (accuracy refers to the percentage of correctly classified samples over all test samples) was obtained. X axis refers to Δ value, it increases from 0 to 10. Y axis refers to the accuracy obtained in chromosome 21 when using our method, it fluctuates when different Δ values are applied and the highest accuracy is obtained when Δ is equal to 3.1.