Figure 5

Hit region identification functions for High-Risk HPV (a) Functions obtained using prior knowledge on the taxa carcinogenicity. The hit region identification functions Q₄, depicted by a dashed line, Q₅, depicted by a continuous line, and Q₆, depicted by a dotted line, for the High-Risk HPV (HPV-16 and 18) [11, 12], during the scan of the gene E6. (b) Functions computed without prior knowledge on the taxa carcinogenicity. The hit region identification functions Q'₄, depicted by a dashed line, Q'₅, depicted by a continuous line, and Q'₆, depicted by a dotted line, during the scan of the gene E6. The abscissa axis represents the window position along the nucleotide multiple sequence alignment. The PDZ-doirmm is highlighted in gray. Annotations for the N and C-terminal arms, E6N and E6C domains are represented for HPV16 coordinates, from (Nominé et al., 2006) [30]. Zn²⁺-ligating Cys residues annotations reproduced from Lipari et al., 2001 [28].