Table 1 Examples of protein complexes identified by TSN-PCD more precisely in a dynamic network than that identified by HC-PIN in a static network
Best matched complexes identified | Best matched complexes identified | ||||||
|---|---|---|---|---|---|---|---|
Known protein complexes | in static network (HC-PIN) | in dynamic network (TSN-PCD) | |||||
Complexes | Proteins | #. Pc | Size(Overlap) | OS | #. Pc | Size(Overlap) | OS |
Dig1p/Ste12p/Dig2p complex | DIG1;DIG2;STE12 | 43 | 4(3) | 0.75 | 302 | 3(3) | 1.00 |
AP-3 adaptor complex | APL5;APL6;APM3; | 109 | 3(3) | 0.75 | 77 | 4(4) | 1.00 |
APS3 | |||||||
SAS complex | SAS2;SAS4;SAS5 | 122 | 11(3) | 0.27 | 404 | 3(3) | 1.00 |
MRX complex | MRE11;RAD50;XRS2 | 39 | 4(1) | 0.083 | 218 | 3(3) | 1.00 |
prefoldin complex | GIM3;GIM4;GIM5; | 8 | 11(5) | 0.45 | 107 | 6(5) | 0.83 |
PAC10;PFD1;YKE2 | |||||||
AP-1 adaptor complex | APL2;APL4;APM1; | 116 | 6(4) | 0.67 | 401 | 5(4) | 0.8 |
APS1 | |||||||
DASH complex | ASK1;DAD1;DAD2; | 56 | 36(7) | 0.15 | 857 | 7(7) | 0.78 |
DAD3;DAD4;DAM1 | |||||||
DUO1;SPC19;SPC34 | |||||||
FBP degradation complex | RMD5;GID7;GID8; | 83 | 4(3) | 0.28 | 586 | 8(7) | 0.77 |
VID24;VID28;VID30 | |||||||
FYV10;YDL176W | |||||||
ARGR complex | ARG80;ARG81;ARG82; | 26 | 6(4) | 0.67 | 158 | 3(3) | 0.75 |
MCM1 | |||||||
retromer complex | PEP8;VPS29;VPS35 | 72 | 5(3) | 0.6 | 45 | 4(3) | 0.75 |
alpha DNA polymerase:primase complex | POL1;POL12;PRI1; | 110 | 12(3) | 0.19 | 709 | 3(3) | 0.75 |
PRI2 | |||||||
Sec62p/Sec63p complex | SEC62;SEC63;SEC66; | 75 | 129(1) | 0.002 | 584 | 3(3) | 0.75 |
SEC72 | |||||||
Kornberg’s mediator (SRB) complex | SSN3;SSN8;SRB8; | 50 | 54(20) | 0.30 | 552 | 19(18) | 0.68 |
SSN2;CSE2;GAL11 | |||||||
MED1;MED11;MED2 | |||||||
MED4;MED6;MED7 | |||||||
MED8;NUT1;NUT2 | |||||||
PGD1;RGR1;ROX3 | |||||||
SIN4;SRB2;SRB4 | |||||||
SRB5;SRB6;SRB7 | |||||||
SOH1 | |||||||