Table 2 Description of fold recognition methods used by MetaDisorder
From: MetaDisorder: a meta-server for the prediction of intrinsic disorder in proteins
Method | Short description | Availability | Ref. |
|---|---|---|---|
PSI-BLAST | Position-Specific Iterated BLAST uses position-specific scoring matrices derived during the search of the nr database | local installation | [37] |
FFAS | Profile-profile alignment and fold-recognition algorithm for fold and function assignment | local installation | [35] |
mGenThreader | The method combines profile-profile alignments with secondary-structure specific gap-penalties, classic pair- and solvation potentials using a linear combination optimized with a regression SVM model | local installation | [36] |
HHsearch | Generalizes the alignment of protein sequences with a profile hidden Markov model (HMM) to the case of pairwise alignment of profile HMMs | local installation | [34] |
PCONS | A neural-network-based consensus predictor | local installation | [39] |
PHYRE | An algorithm that uses profile-profile and secondary structure matching algorithm | web service | [38] |