Regulatory networks of CMI-COMBINER biomarkers The pink/green nodes denote up-/down-regulation of gene expression. The orange nodes indicate contradictory regulation in different datasets. Larger nodes are highly connected in the network; most are overlaps between CMI- and CORG-COMBINER. The three well-known oncogenes for breast cancer metastasis-TP53, BRCA1, and ERBB2-were enlarged further. The core module markers were reassembled into an overall interaction network. Known functional modules neatly overlay well-connected clusters. Many of the highly connected genes are known "driver" genes playing an important role in breast cancer metastasis.