Table 2 Confident "driver" genes for breast cancer metastasis
From: Core module biomarker identification with network exploration for breast cancer metastasis
Symbol | Entrez | Description |
|---|---|---|
MAP2K1 [32] | 5604 | mitogen-activated protein kinase kinase 1 |
E2F1 [14] | 1869 | E2F transcription factor 1 |
GRB2 [33] | 2885 | growth factor receptor-bound protein 2 |
NFKB1 [34] | 4790 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
RB1 [35] | 5925 | retinoblastoma 1 |
BRCA1 [36] | 672 | breast cancer 1, early onset |
FOS [37] | 2353 | v-fos FBJ murine osteosarcoma viral oncogene homolog |
SOS1 [38] | 6654 | son of sevenless homolog 1 (Drosophila) |
PIK3CA [39] | 5290 | phosphoinositide-3-kinase, catalytic, alpha polypeptide |
JAK1 [40] | 3716 | Janus kinase 1 |
SHC1 [41] | 6464 | SHC (Src homology 2 domain containing) transforming protein 1 |
MYC [42] | 4609 | v-myc myelocytomatosis viral oncogene homolog (avian) |
CCNA2 [37] | 890 | cyclin A2 |