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Table 7 False positive rates when null hypothesis is simulated by generating random expression data

From: Down-weighting overlapping genes improves gene set analysis

 

α= 0.05

α= 0.01

PADOG

0.051

0.012

GSA

0.052

0.015

GSEA

0.052

0.012

  1. The fraction of all pathways significant at α=0.05 and α=0.01 were computed after applying the three analysis methods on 1200 datasets having expression data generated from a random normal N(0,1) distribution. The collection of gene sets used in the analysis was defined by the 229 KEGG non-metabolic and metabolic pathways.
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BMC Bioinformatics

ISSN: 1471-2105

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