Developing a powerful In Silico tool for the discovery of novel caspase-3 substrates: a preliminary screening of the human proteome

Table 2 Significantly enriched GO terms

GO ID	GO Term	P-value	Term in predicted proteins	Term in human genome
GO:0007155	cell adhesion	1.02E-39	322	885
GO:0022008	neurogenesis	3.97E-27	324	1016
GO:0007049	cell cycle	2.71E-26	376	1250
GO:0030030	cell projection organization	6.53E-26	263	776
GO:0009966	regulation of signal transduction	6.37E-23	399	1399
GO:0007010	cytoskeleton organization	9.69E-21	217	641
GO:0051276	chromosome organization	8.07E-20	212	630
GO:0000902	cell morphogenesis	1.35E-19	228	698
GO:0040011	locomotion	4.84E-18	310	1071
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	6.98E-16	227	737
GO:0009790	embryo development	9.49E-15	245	830

The GO terms of the listed biological processes were manually filtered, to reduce redundancy, by removing general roots (parents) and detailed leaves (children) of the enriched GO terms that were obtained by ToppFun tool. The P-value of each GO term in the predicted caspase-3 proteins was derived by random sampling of the whole genome.

ISSN: 1471-2105