Comparison of CMF based QSAR modeling with ridge regression and SVR on the inhibitors of Hedgehog Signaling Pathway. The compounds are represented with Drug-like index and General Descriptor respectively. The whole data was partitioned randomly with selecting 2/3 data as training dataset and 1/3 data as testing dataset. The whole procedure was repeated 10 times and the averaged performance was calculated. Cell line No. 1–4 corresponding to BxPC-3, NCI-H446, SW1990 and NCI-H157 respectively.