Figure 1

Different column patterns in an MSA. Schematic representation of an MSA and its phylogenetic tree (left). Conserved position is highlighted in red, coevolved positions in green and orange and putative SDPs in yellow and blue. On the top are indicated the column pattern and on the bottom, the suitable method to detect each kind of position (C: conservation score; cMI: cumulative MI; ivET: integer value ET; rvET: real value ET; XDET and SDPfox are also indicated).