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Table 3 The 20 genes in EcoCyc and BsubCyc with the highest influence scores

From: Regulatory network operations in the Pathway Tools software

E. coli K-12

B. subtilis

Gene

Product Role

Score

Direct Targets

Gene

Product Role

Score

Direct Targets

rpoD

sigma-70 factor

100

2282

sigA

sigma-43 factor

100

863

rpoE

sigma-24 factor

44

550

sigB

sigma-37 factor

75

101

crp

cAMP receptor protein

36

465

spo0A

response regulator

55

88

lexA

SOS response transcriptional repressor

32

56

sigE

sporulation-specific sigma-29 factor

51

128

ihfA

integration host factor, α-subunit

26

225

spoIVCB

sporulation-specific sigma-K factor precursor (N-terminal half)

46

101

ihfB

integration host factor, β-subunit

26

225

spoIIIC

sporulation-specific sigma-K factor precursor (C-terminal half)

46

101

rpoS

sigma-S factor

26

316

spoIIID

sporulation-specific transcriptional regulator

46

37

rpoH

sigma-32 factor

25

450

gerE

transcriptional regulator

34

104

cpxR

stress response regulator

23

58

abrB

regulator of transition state genes

25

100

fis

factor for inversion stimulation

19

223

sigH

sigma-30 factor

22

21

gadX

acid resistance system regulator

14

28

rok

repressor of comK

3

27

fur

ferric uptake regulator

13

131

comK

competence transcription factor

3

55

arcA

anaerobic response regulator

11

160

degU

two-component response regulator

1.6

19

hns

histone-like nucleoid structuring protein

11

174

codY

GTP and BCAA-dependent transcriptional regulator

1.6

63

fnr

aerobic to anaerobic transition regulator

10

294

sinR

post-exponential phase response regulator

1.6

21

dnaA

chromosomal replication initiator protein

8.2

12

med

positive regulator of comK

1.6

1

cytR

cytidine repressor

8.2

12

scoC

extracellular protease production and sporulation regulator

0.8

16

nsrR

nitrite-sensitive repressor

6.8

83

senS

transcriptional activator

0.8

2

rpoN

sigma-54 factor

6.4

179

salA

Mrp family regulator

0.4

1

gadE

acid resistance system regulator

5.4

36

sigG

sporulation-specific sigma-G factor

0.4

84