Figure 4

Shabtai et al. Comparison of several correlation method outcomes using TAG4 Microarray dataset. Four correlation methods applied to the same dataset were clustered to show the performance of BE compared to other methods. The left column displays the cluster of experiments where the labels are the dates on which the experiment was performed (a, c, e, g). Adjacent identical dates are displayed in a red rectangle to indicate when clustering occurs by date. The right column displays the cluster of experiments where the labels are the chemical compound that was used for each experiment (b, d, f, h). Adjacent identical chemical compounds are displayed in a green rectangle to indicate when the same chemical compounds are clustering together. The desired result of a cluster is that similar conditions will cluster together. Examining the Pearson correlation cluster, the experiments cluster by date (a), due to a date batch effect. The BE method minimized the batch effect where identical dates did not cluster together (g), while identical conditions (chemical compounds) did cluster together (h).