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Table 4 Comparison between predicted CRMs and experimentally validated heart enhancers

From: Predicting tissue specific cis-regulatory modules in the human genome using pairs of co-occurring motifs

n CNEs PCRMs Sensitivity Expected P-value
0 12 10 83% 1.7 1.1e−11
10 13 9 69% 1.9 8.0e−09
20 15 10 67% 0.9 0.0
30 15 11 73% 1.3 0.0
40 15 8 53% 1.3 1.9e−10
60 15 9 60% 1.0 4.4e−16
80 15 11 73% 1.0 0.0
100 16 9 56% 0.6 0.0
All 16 5 31% 0.5 1.0e−11
  1. We calculated the overlaps of the CNEs found in the 154 heart-specific loci and the putative CRMs (PCRMs) with 95 experimentally validated heart enhancers [9]. Columns CNEs and PCRMs display the number of overlaps between the CNEs and heart enhancers, and the PCRMs and heart enhancer, respectively. The expected number is the average overlap between a random CNE set and the heart enhancers. We selected 10000 random sets as before. The P-values were based on the Z-scores calculated from the distribution of the overlaps in the 10000 trials.