n | CNEs | PCRMs | Sensitivity | Expected | P-value |
|---|
0 | 12 | 10 | 83% | 1.7 | 1.1e−11 |
10 | 13 | 9 | 69% | 1.9 | 8.0e−09 |
20 | 15 | 10 | 67% | 0.9 | 0.0 |
30 | 15 | 11 | 73% | 1.3 | 0.0 |
40 | 15 | 8 | 53% | 1.3 | 1.9e−10 |
60 | 15 | 9 | 60% | 1.0 | 4.4e−16 |
80 | 15 | 11 | 73% | 1.0 | 0.0 |
100 | 16 | 9 | 56% | 0.6 | 0.0 |
All | 16 | 5 | 31% | 0.5 | 1.0e−11 |
- We calculated the overlaps of the CNEs found in the 154 heart-specific loci and the putative CRMs (PCRMs) with 95 experimentally validated heart enhancers [9]. Columns CNEs and PCRMs display the number of overlaps between the CNEs and heart enhancers, and the PCRMs and heart enhancer, respectively. The expected number is the average overlap between a random CNE set and the heart enhancers. We selected 10000 random sets as before. The P-values were based on the Z-scores calculated from the distribution of the overlaps in the 10000 trials.
