Figure 7

Interaction graph derived from the PIM depicted in Figure4. The L-nodes A, R and B represent the basal activity of the molecules; the remaining L-nodes represent binding and modification sites. Solid edges denote activations; dotted edges can have a positive or negative sign. L-node A_b1 and R_b1 both arise from the binding process represented by P-node 1 in Figure4 and neither A_b1 nor R_b1 is subject to a modification process. Hence, one is free to associate either A_b1 or R_b1 to P-node 1 (here L-node R_b1 is chosen and consequently an activating (solid) edge is inserted from A_b1 to R_b1, see main text). L-node R_b1 corresponds to P-node 1 in Figure4, L-node R_p1 to P-node 2, L-node R_p2 to P-node 3 and L-node B_b1 to P-node 4; the dotted edges correspond to edges between these P-nodes in Figure4.