Table 2 The FS methods sorted by the AUC metric achieved in validation test for each neuromuscular disease using the RF classifier
| Â | FS methods | 5-CV | Hold-out Validation | ||||
|---|---|---|---|---|---|---|---|
AUC | TNR | TPR | AUC | TNR | TPR | ||
ALS | m AP -KL | 1.00 (0.00) | 1.00 (0.00) | 0.98 (0.14) | 1.00 | 1.00 | 1.00 |
BGA-COA | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
cat | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
eBayes | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
maxT | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
maxT (200) | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
ODP | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
PCA | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
PLS-CV | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
SAM | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
SNR | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
t-test | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
RF-MDA | 1.00 (0.00) | 1.00 (0.00) | 0.93 (0.25) | 1.00 | 1.00 | 1.00 | |
Rnd | 1.00 (0.00) | 1.00 (0.01) | 1.00 (0.00) | 0.99 | 0.92 | 0.97 | |
HykGene | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.64 | 0.42 | 0.67 | |
DMD | m AP -KL | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.91 | 1.00 |
BGA-COA | 0.98 (0.14) | 0.85 (0.32) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
cat | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
eBayes | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.91 | 1.00 | |
HykGene | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
maxT | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
maxT (200) | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
ODP | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
PLS-CV | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
RF-MDA | 1.00 (0.00) | 1.00 (0.00) | 0.99 (0.07) | 1.00 | 1.00 | 1.00 | |
SAM | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
SNR | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
t-test | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
Rnd | 1.00 (0.00) | 0.99 (0.04) | 1.00 (0.00) | 0.99 | 0.96 | 0.93 | |
PCA | 0.48 (0.42) | 0.48 (0.46) | 0.41 (0.45) | 0.61 | 0.55 | 0.67 | |
JDM | m AP -KL | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 |
HykGene | 1.00 (0.00) | 1.00 (0.00) | 0.95 (0.15) | 1.00 | 1.00 | 1.00 | |
maxT | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
maxT (200) | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
PCA | 0.90 (0.19) | 0.77 (0.31) | 0.73 (0.32) | 1.00 | 1.00 | 1.00 | |
PLS-CV | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
RF-MDA | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
SAM | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
t-test | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
BGA-COA | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.88 | 1.00 | |
eBayes | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.88 | 1.00 | |
ODP | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.88 | 1.00 | |
SNR | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.88 | 1.00 | |
cat | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.88 | 1.00 | |
Rnd | 1.00 (0.00) | 1.00 (0.00) | 0.99 (0.03) | 1.00 | 0.99 | 0.98 | |
LGMD2A | FS methods | 5-CV | Hold-out Validation | ||||
AUC | TNR | TPR | AUC | TNR | TPR | ||
m AP -KL | 1.00 (0.00) | 0.87 (0.30) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
BGA-COA | 1.00 (0.00) | 0.96 (0.17) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
maxT (200) | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 1.00 | 1.00 | |
PLS-CV | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.91 | 1.00 | |
ODP | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.73 | 1.00 | |
RF-MDA | 1.00 (0.00) | 0.98 (0.10) | 1.00 (0.00) | 1.00 | 0.73 | 1.00 | |
SAM | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.64 | 1.00 | |
cat | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.64 | 1.00 | |
t-test | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.64 | 1.00 | |
eBayes | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.36 | 1.00 | |
HykGene | 1.00 (0.00) | 0.97 (0.12) | 0.98 (0.10) | 0.94 | 0.45 | 1.00 | |
maxT | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.94 | 0.45 | 1.00 | |
SNR | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.94 | 0.73 | 1.00 | |
Rnd | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.89 | 0.70 | 0.93 | |
PCA | 0.83 (0.30) | 0.61 (0.43) | 0.77 (0.39) | 0.58 | 0.27 | 1.00 | |
LGMD2B | RF-MDA | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.73 | 1.00 |
maxT (200) | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.64 | 1.00 | |
PLS-CV | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 1.00 | 0.55 | 1.00 | |
BGA-COA | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.98 | 0.73 | 1.00 | |
maxT | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.91 | 0.64 | 1.00 | |
Rnd | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.90 | 0.56 | 1.00 | |
SNR | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.88 | 0.73 | 1.00 | |
HykGene | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.82 | 0.64 | 1.00 | |
t-test | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.82 | 0.73 | 0.67 | |
ODP | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.73 | 0.45 | 1.00 | |
mAP-KL | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.70 | 0.36 | 0.67 | |
SAM | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.52 | 0.27 | 1.00 | |
eBayes | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.48 | 0.27 | 0.67 | |
cat | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.36 | 0.09 | 1.00 | |
PCA | 0.89 (0.25) | 0.74 (0.38) | 0.61 (0.44) | 0.21 | 0.09 | 1.00 | |
NM | SNR | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.90 | 0.77 | 1.00 |
t-test | 1.00 (0.00) | 0.98 (0.10) | 1.00 (0.00) | 0.89 | 0.77 | 0.80 | |
HykGene | 1.00 (0.00) | 1.00 (0.00) | 0.99 (0.07) | 0.88 | 0.69 | 0.80 | |
maxT (200) | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.80 | 0.69 | 0.80 | |
cat | 1.00 (0.00) | 1.00 (0.00) | 0.99 (0.07) | 0.78 | 0.46 | 1.00 | |
mAP-KL | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.74 | 0.69 | 0.60 | |
Rnd | 0.98 (0.03) | 0.87 (0.09) | 0.96 (0.06) | 0.67 | 0.49 | 0.76 | |
SAM | 1.00 (0.00) | 0.87 (0.28) | 0.98 (0.10) | 0.65 | 0.15 | 1.00 | |
PCA | 0.82 (0.30) | 0.77 (0.35) | 0.73 (0.39) | 0.55 | 0.92 | 0.40 | |
BGA-COA | 0.96 (0.14) | 0.87 (0.28) | 0.91 (0.19) | 0.47 | 0.23 | 0.60 | |
PLS-CV | 0.97 (0.12) | 0.87 (0.28) | 0.99 (0.07) | 0.42 | 0.08 | 1.00 | |
maxT | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.37 | 0.38 | 0.40 | |
ODP | 1.00 (0.00) | 0.92 (0.23) | 1.00 (0.00) | 0.25 | 0.38 | 0.20 | |
RF-MDA | 1.00 (0.00) | 1.00 (0.00) | 1.00 (0.00) | 0.22 | 0.15 | 0.60 | |
eBayes | - | - | - | - | - | - | |